Protective Role of Astrocytic Leptin Signaling Against Excitotoxicity
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منابع مشابه
Protective role of licochalcone B against ethanol-induced hepatotoxicity through regulation of Erk signaling
Objective(s): Oxidative stress has been established as a key cause of alcohol-induced hepatotoxicity. Licochalcone B, an extract of licorice root, has shown antioxidative properties. This study was to investigate the effects and mechanisms of licochalcone B in ethanol-induced hepatic injury in an in vitro study. Materials and Methods: An in vitro model of Ethanol-induced cytotoxicity in BRL cel...
متن کاملprotective role of licochalcone b against ethanol-induced hepatotoxicity through regulation of erk signaling
objective(s): oxidative stress has been established as a key cause of alcohol-induced hepatotoxicity. licochalcone b, an extract of licorice root, has shown antioxidative properties. this study was to investigate the effects and mechanisms of licochalcone b in ethanol-induced hepatic injury in an in vitro study. materials and methods: an in vitro model of ethanol-induced cytotoxicity in brl cel...
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Objective: Irinotecan is a botanical derivative and an anti-cancer drug with cytotoxic and genotoxic effects. The present study evaluated the effect of Lactobacillus plantarum A7 on the genotoxic activity of irinotecan in a hepatocellular carcinoma cell line (HepG2) by comet assay. Materials and Methods: HepG2 were incubated with irinotecan (100 µM), heat-killed cells (0.025 µg/ml) + irinotecan...
متن کاملThe Astrocytic Contribution in ALS: Inflammation and Excitotoxicity
Amyotrophic Lateral Sclerosis (ALS) is a devastating progressive neurodegenerative disease, due to the loss of motor neurons and denervation of muscle fibres, resulting in increasing muscle weakness and paralysis. The disease has an incidence of 2.7 cases per 100,000 people in Europe (Longroscino et al., 2010). It is diagnosed from teen years onward, but is more prevalent in the later years of ...
متن کاملIn vivo studies on the protective role of minocycline against excitotoxicity caused by malonate or N-methyl-d-aspartate.
Minocycline has been shown to exert neuroprotection against a wide variety of toxic insults both in vitro and in vivo. However, contradictory results have recently been reported. We now report that minocycline affords no protection against the neurotoxicity caused by malonate or N-methyl-d-aspartate (NMDA). Rats were treated with minocycline (45 mg/kg i.p. x 7) every 12 h. Thirty minutes after ...
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ژورنال
عنوان ژورنال: Journal of Molecular Neuroscience
سال: 2012
ISSN: 0895-8696,1559-1166
DOI: 10.1007/s12031-012-9924-0